Analysis Tools
vision/eye
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• at P2, levels of apoptosis in the epithelium are increased compared to in wild-type mice
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• in the anterior, posterior, and center of the lens
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• lenses exhibit an abnormal shape with shortened anterior-posterior dimension
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• denucleation of the fiber cell compartment is delayed compared to in wild-type mice
• anterior and posterior suture formation is defective
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• at E13.5, lens epithelium is thickened and contains disorganized areas unlike in wild-type mice due to increased cell numbers
• at P2, the integrity of the lens epithelium is severely disrupted compared to in wild-type mice
• the central epithelium in lenses appears flattened and the uniform positioning of nuclei within cells is lost unlike in wild-type mice
• lens contain loosely packed cells, clusters of nuclei followed by gaps in the row of nuclei and vacuoles along with a few areas of multilayering in the peripheral epithelium unlike in wild-type mice
• however, at P2 the number of epithelial cells is normal
• at P24, a few areas of multilayering and irregular nuclei shapes are still observed in the peripheral epithelium and the central epithelium remained flattened unlike in wild-type mice
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• in some mice fiber cells fail to exhibit convex curvature and in other cases have an irregular curvature unlike in wild-type mice
• differentiation of fiber cells is disrupted
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• at P2
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cellular
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• at P2, levels of apoptosis in the epithelium are increased compared to in wild-type mice
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• in the anterior, posterior, and center of the lens
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