Phenotypes Associated with This Genotype

Genotype
MGI:4354591

• Allelic Composition: Itk^tm1Ljb/Itk^tm1Ljb; Txk^tm1Pls/Txk^tm1Pls
• Genetic Background: B6.129-Txk^tm1Pls Itk^tm1Ljb

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased CD8-positive, alpha-beta T cell number ( J:113408 )

• vast majority of T cells have a memory cell phenotype including the ability to produce IFN-gamma upon ex vivo stimulation and upregulation of Bcl-xL in response to IL-15

increased memory T cell number ( J:113408 )

• majority of single-positive CD8⁺ T cell in the thymus have morphological characteristics similar to memory T cells (CD25^lo, CD44^hi, CD69^lo, CD122⁺, HSA^lo and NK1.1^int)

• 85% of peripheral CD8⁺ T cells are memory T cells based on surface markers

• memory T cell phenotype is confirmed functionally in that a large proportion of T cells produce IFN-gamma upon ex vivo stimulation and that they upregulate Bcl-xL in response to IL-15

abnormal CD8-positive, alpha-beta T cell physiology ( J:113408 )

• single-positive CD8⁺ T cell numbers are increased 3-fold in the thymus

increased interferon-gamma secretion ( J:113408 )

• CD8⁺ T cells have increased secretion of IFN-gamma upon ex vivo stimulation by PMA and ionomycin

hematopoietic system

increased CD8-positive, alpha-beta T cell number ( J:113408 )

• vast majority of T cells have a memory cell phenotype including the ability to produce IFN-gamma upon ex vivo stimulation and upregulation of Bcl-xL in response to IL-15

increased memory T cell number ( J:113408 )

• majority of single-positive CD8⁺ T cell in the thymus have morphological characteristics similar to memory T cells (CD25^lo, CD44^hi, CD69^lo, CD122⁺, HSA^lo and NK1.1^int)

• 85% of peripheral CD8⁺ T cells are memory T cells based on surface markers

• memory T cell phenotype is confirmed functionally in that a large proportion of T cells produce IFN-gamma upon ex vivo stimulation and that they upregulate Bcl-xL in response to IL-15

abnormal CD8-positive, alpha-beta T cell physiology ( J:113408 )

• single-positive CD8⁺ T cell numbers are increased 3-fold in the thymus