immune system
• when stimulated with low concentrations of antigen, CD4 T cells differentiate predominately into a Th1 phenotype while controls develop into a Th2 phenotype
• these T cells have increased expression of the T-bet transcription factor
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• T cells cultured under Th1 polarizing conditions produce less IFN-gamma than controls
• Th1 T cells produce 1.5- to 200-fold less IFN-gamma than controls
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• T cells cultured under Th2 polarizing conditions produce less IL-10 than controls
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• T cells cultured under Th2 polarizing conditions produce less IL-4 than controls
• Th2 T cells produce 3.5- to 300-fold less IL-4 than controls
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• T cells cultured under Th2 polarizing conditions produce less IL-5 than controls
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hematopoietic system
• when stimulated with low concentrations of antigen, CD4 T cells differentiate predominately into a Th1 phenotype while controls develop into a Th2 phenotype
• these T cells have increased expression of the T-bet transcription factor
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