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Phenotypes Associated with This Genotype
Genotype
MGI:4354514
Allelic
Composition
Itktm1Ljb/Itktm1Ljb
Rag1tm1Mom/Rag1tm1Mom
Tg(Tcra5CC7,Tcrb5CC7)IWep/?
Genetic
Background
involves: 129 * C57BL/10
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itktm1Ljb mutation (0 available); any Itk mutation (51 available)
Rag1tm1Mom mutation (56 available); any Rag1 mutation (132 available)
Tg(Tcra5CC7,Tcrb5CC7)IWep mutation (5 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• when stimulated with low concentrations of antigen, CD4 T cells differentiate predominately into a Th1 phenotype while controls develop into a Th2 phenotype
• these T cells have increased expression of the T-bet transcription factor
• T cells cultured under Th1 polarizing conditions produce less IFN-gamma than controls
• Th1 T cells produce 1.5- to 200-fold less IFN-gamma than controls
• T cells cultured under Th2 polarizing conditions produce less IL-10 than controls
• T cells cultured under Th2 polarizing conditions produce less IL-4 than controls
• Th2 T cells produce 3.5- to 300-fold less IL-4 than controls
• T cells cultured under Th2 polarizing conditions produce less IL-5 than controls

hematopoietic system
• when stimulated with low concentrations of antigen, CD4 T cells differentiate predominately into a Th1 phenotype while controls develop into a Th2 phenotype
• these T cells have increased expression of the T-bet transcription factor


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/25/2025
MGI 6.24
The Jackson Laboratory