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Phenotypes Associated with This Genotype
Genotype
MGI:4354504
Allelic
Composition
Pou2af1tm1Pjln/Pou2af1tm1Pjln
Tg(tetO-Pou2af1)1Pjln/0
Tg(tTA)1Pjln/0
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pou2af1tm1Pjln mutation (0 available); any Pou2af1 mutation (15 available)
Tg(tetO-Pou2af1)1Pjln mutation (0 available)
Tg(tTA)1Pjln mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• unlike in Pou2af1tm1Pjln homozygotes, mice exhibit normal numbers of pro-, pre-, immature, and transitional immature B cells and normal rates of B cell apoptosis
• in the spleen
• serum levels of secondary immunoglobins are greatly reduced compared to in wild-type mice

hematopoietic system
• in the spleen
• serum levels of secondary immunoglobins are greatly reduced compared to in wild-type mice


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/18/2025
MGI 6.24
The Jackson Laboratory