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Phenotypes Associated with This Genotype
Genotype
MGI:4354296
Allelic
Composition
Apoetm1Unc/Apoetm1Unc
Lpltm1Sem/Lpltm1Sem
Genetic
Background
involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoetm1Unc mutation (22 available); any Apoe mutation (64 available)
Lpltm1Sem mutation (0 available); any Lpl mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• following carotid injury with ferric chloride, neointimal area is greater than in similarly treated Apoetm1Unc homozygotes (J:151434)
• however, the medial area of the healing blood vessel is normal (J:151434)
• following carotid injury with ferric chloride, the intima to media ratio is increased compared to in similarly treated Apoetm1Unc homozygotes (J:151434)
• following carotid injury with ferric chloride, neointimal hyperplasia induces more pronounced luminal stenosis than in similarly treated Apoetm1Unc homozygotes (J:151434)
• following carotid injury with ferric chloride, mice develop severe occlusive thrombi with complete degradation of the medial elastic fibers unlike in similarly treated Apoetm1Unc homozygotes (J:151434)
• following carotid injury with ferric chloride, neointimal area is greater than in similarly treated Apoetm1Unc homozygotes (J:151434)
• however, the medial area of the healing blood vessel is normal (J:151434)
• following carotid injury with ferric chloride, the intima to media ratio is increased compared to in similarly treated Apoetm1Unc homozygotes (J:151434)
• following carotid injury with ferric chloride, neointimal hyperplasia induces more pronounced luminal stenosis than in similarly treated Apoetm1Unc homozygotes (J:151434)
• following carotid injury with ferric chloride, mice develop severe occlusive thrombi with complete degradation of the medial elastic fibers unlike in similarly treated Apoetm1Unc homozygotes (J:151434)
• unlike Apoetm1Unc homozygotes, mice fail to exhibit an increase in plasma triglyceride and cholesterol levels following carotid artery injury with ferric chloride and high cholesterol diet (J:151434)
• unlike Apoetm1Unc homozygotes, mice fail to exhibit an increase in plasma triglyceride and cholesterol levels following carotid artery injury with ferric chloride and high cholesterol diet (J:151434)
• unlike Apoetm1Unc homozygotes, mice fail to exhibit an increase in plasma cholesterol levels following carotid artery injury with ferric chloride and high cholesterol diet (J:151434)
• unlike Apoetm1Unc homozygotes, mice fail to exhibit an increase in plasma cholesterol levels following carotid artery injury with ferric chloride and high cholesterol diet (J:151434)
• pre-injury and at 12 weeks following aortic injury with ferric chloride, mice exhibit increased plasma cholesterol and non-HDL cholesterol levels compared with Apoetm1Unc homozygotes (J:151434)
• pre-injury and at 12 weeks following aortic injury with ferric chloride, mice exhibit increased plasma cholesterol and non-HDL cholesterol levels compared with Apoetm1Unc homozygotes (J:151434)
• pre-injury and at 12 weeks following aortic injury with ferric chloride, mice exhibit increased plasma triglyceride levels compared with Apoetm1Unc homozygotes (J:151434)
• pre-injury and at 12 weeks following aortic injury with ferric chloride, mice exhibit increased plasma triglyceride levels compared with Apoetm1Unc homozygotes (J:151434)
• at 12 weeks following aortic injury with ferric chloride, mice exhibit severe combined hyperlipidemia compared with Apoetm1Unc homozygotes (J:151434)
• at 12 weeks following aortic injury with ferric chloride, mice exhibit severe combined hyperlipidemia compared with Apoetm1Unc homozygotes (J:151434)
• following carotid injury with ferric chloride, mice develop severe occlusive thrombi with complete degradation of the medial elastic fibers unlike in similarly treated Apoetm1Unc homozygotes (J:151434)
• following carotid injury with ferric chloride, mice develop severe occlusive thrombi with complete degradation of the medial elastic fibers unlike in similarly treated Apoetm1Unc homozygotes (J:151434)

cardiovascular system
• following carotid injury with ferric chloride, neointimal area is greater than in similarly treated Apoetm1Unc homozygotes (J:151434)
• however, the medial area of the healing blood vessel is normal (J:151434)
• following carotid injury with ferric chloride, the intima to media ratio is increased compared to in similarly treated Apoetm1Unc homozygotes (J:151434)
• following carotid injury with ferric chloride, neointimal hyperplasia induces more pronounced luminal stenosis than in similarly treated Apoetm1Unc homozygotes (J:151434)
• following carotid injury with ferric chloride, mice develop severe occlusive thrombi with complete degradation of the medial elastic fibers unlike in similarly treated Apoetm1Unc homozygotes (J:151434)
• following carotid injury with ferric chloride, neointimal area is greater than in similarly treated Apoetm1Unc homozygotes (J:151434)
• however, the medial area of the healing blood vessel is normal (J:151434)
• following carotid injury with ferric chloride, the intima to media ratio is increased compared to in similarly treated Apoetm1Unc homozygotes (J:151434)
• following carotid injury with ferric chloride, neointimal hyperplasia induces more pronounced luminal stenosis than in similarly treated Apoetm1Unc homozygotes (J:151434)
• following carotid injury with ferric chloride, mice develop severe occlusive thrombi with complete degradation of the medial elastic fibers unlike in similarly treated Apoetm1Unc homozygotes (J:151434)

Mouse Models of Human Disease
OMIM ID Ref(s)
Hyperlipidemia, Familial Combined; FCHL 144250 J:151434


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/26/2016
MGI 6.02
The Jackson Laboratory