Mouse Genome Informatics
cx
    Apoetm1Unc/Apoetm1Unc
Lpltm1Sem/Lpltm1Sem

involves: 129P2/OlaHsd
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
homeostasis/metabolism
• following carotid injury with ferric chloride, neointimal area is greater than in similarly treated Apoetm1Unc homozygotes
• however, the medial area of the healing blood vessel is normal
• following carotid injury with ferric chloride, the intima to media ratio is increased compared to in similarly treated Apoetm1Unc homozygotes
• following carotid injury with ferric chloride, neointimal hyperplasia induces more pronounced luminal stenosis than in similarly treated Apoetm1Unc homozygotes
• following carotid injury with ferric chloride, mice develop severe occlusive thrombi with complete degradation of the medial elastic fibers unlike in similarly treated Apoetm1Unc homozygotes
• unlike Apoetm1Unc homozygotes, mice fail to exhibit an increase in plasma triglyceride and cholesterol levels following carotid artery injury with ferric chloride and high cholesterol diet
• unlike Apoetm1Unc homozygotes, mice fail to exhibit an increase in plasma cholesterol levels following carotid artery injury with ferric chloride and high cholesterol diet
• pre-injury and at 12 weeks following aortic injury with ferric chloride, mice exhibit increased plasma cholesterol and non-HDL cholesterol levels compared with Apoetm1Unc homozygotes
• pre-injury and at 12 weeks following aortic injury with ferric chloride, mice exhibit increased plasma triglyceride levels compared with Apoetm1Unc homozygotes
• at 12 weeks following aortic injury with ferric chloride, mice exhibit severe combined hyperlipidemia compared with Apoetm1Unc homozygotes
• following carotid injury with ferric chloride, mice develop severe occlusive thrombi with complete degradation of the medial elastic fibers unlike in similarly treated Apoetm1Unc homozygotes

cardiovascular system
• following carotid injury with ferric chloride, neointimal area is greater than in similarly treated Apoetm1Unc homozygotes
• however, the medial area of the healing blood vessel is normal
• following carotid injury with ferric chloride, the intima to media ratio is increased compared to in similarly treated Apoetm1Unc homozygotes
• following carotid injury with ferric chloride, neointimal hyperplasia induces more pronounced luminal stenosis than in similarly treated Apoetm1Unc homozygotes
• following carotid injury with ferric chloride, mice develop severe occlusive thrombi with complete degradation of the medial elastic fibers unlike in similarly treated Apoetm1Unc homozygotes

Mouse Models of Human Disease
OMIM IDRef(s)
Hyperlipidemia, Familial Combined; FCHL 144250 J:151434