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Phenotypes Associated with This Genotype
Genotype
MGI:4354296
Allelic
Composition
Apoetm1Unc/Apoetm1Unc
Lpltm1Sem/Lpltm1Sem
Genetic
Background
involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoetm1Unc mutation (22 available); any Apoe mutation (68 available)
Lpltm1Sem mutation (0 available); any Lpl mutation (18 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• following carotid injury with ferric chloride, neointimal area is greater than in similarly treated Apoetm1Unc homozygotes
• however, the medial area of the healing blood vessel is normal
• following carotid injury with ferric chloride, the intima to media ratio is increased compared to in similarly treated Apoetm1Unc homozygotes
• following carotid injury with ferric chloride, neointimal hyperplasia induces more pronounced luminal stenosis than in similarly treated Apoetm1Unc homozygotes
• following carotid injury with ferric chloride, mice develop severe occlusive thrombi with complete degradation of the medial elastic fibers unlike in similarly treated Apoetm1Unc homozygotes
• unlike Apoetm1Unc homozygotes, mice fail to exhibit an increase in plasma triglyceride and cholesterol levels following carotid artery injury with ferric chloride and high cholesterol diet
• unlike Apoetm1Unc homozygotes, mice fail to exhibit an increase in plasma cholesterol levels following carotid artery injury with ferric chloride and high cholesterol diet
• pre-injury and at 12 weeks following aortic injury with ferric chloride, mice exhibit increased plasma cholesterol and non-HDL cholesterol levels compared with Apoetm1Unc homozygotes
• pre-injury and at 12 weeks following aortic injury with ferric chloride, mice exhibit increased plasma triglyceride levels compared with Apoetm1Unc homozygotes
• at 12 weeks following aortic injury with ferric chloride, mice exhibit severe combined hyperlipidemia compared with Apoetm1Unc homozygotes
• following carotid injury with ferric chloride, mice develop severe occlusive thrombi with complete degradation of the medial elastic fibers unlike in similarly treated Apoetm1Unc homozygotes

cardiovascular system
• following carotid injury with ferric chloride, neointimal area is greater than in similarly treated Apoetm1Unc homozygotes
• however, the medial area of the healing blood vessel is normal
• following carotid injury with ferric chloride, the intima to media ratio is increased compared to in similarly treated Apoetm1Unc homozygotes
• following carotid injury with ferric chloride, neointimal hyperplasia induces more pronounced luminal stenosis than in similarly treated Apoetm1Unc homozygotes
• following carotid injury with ferric chloride, mice develop severe occlusive thrombi with complete degradation of the medial elastic fibers unlike in similarly treated Apoetm1Unc homozygotes

Mouse Models of Human Disease
OMIM ID Ref(s)
Hyperlipidemia, Familial Combined; FCHL 144250 J:151434


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory