Phenotypes Associated with This Genotype

Genotype
MGI:4354296

• Allelic Composition: Apoe^tm1Unc/Apoe^tm1Unc; Lpl^tm1Sem/Lpl^tm1Sem
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal vascular wound healing ( J:151434 )

• following carotid injury with ferric chloride, neointimal area is greater than in similarly treated Apoe^tm1Unc homozygotes

• however, the medial area of the healing blood vessel is normal

• following carotid injury with ferric chloride, the intima to media ratio is increased compared to in similarly treated Apoe^tm1Unc homozygotes

• following carotid injury with ferric chloride, neointimal hyperplasia induces more pronounced luminal stenosis than in similarly treated Apoe^tm1Unc homozygotes

• following carotid injury with ferric chloride, mice develop severe occlusive thrombi with complete degradation of the medial elastic fibers unlike in similarly treated Apoe^tm1Unc homozygotes

abnormal circulating lipid level ( J:151434 )

• unlike Apoe^tm1Unc homozygotes, mice fail to exhibit an increase in plasma triglyceride and cholesterol levels following carotid artery injury with ferric chloride and high cholesterol diet

abnormal circulating cholesterol level ( J:151434 )

• unlike Apoe^tm1Unc homozygotes, mice fail to exhibit an increase in plasma cholesterol levels following carotid artery injury with ferric chloride and high cholesterol diet

increased circulating cholesterol level ( J:151434 )

• pre-injury and at 12 weeks following aortic injury with ferric chloride, mice exhibit increased plasma cholesterol and non-HDL cholesterol levels compared with Apoe^tm1Unc homozygotes

increased circulating triglyceride level ( J:151434 )

• pre-injury and at 12 weeks following aortic injury with ferric chloride, mice exhibit increased plasma triglyceride levels compared with Apoe^tm1Unc homozygotes

hyperlipidemia ( J:151434 )

• at 12 weeks following aortic injury with ferric chloride, mice exhibit severe combined hyperlipidemia compared with Apoe^tm1Unc homozygotes

increased susceptibility to induced thrombosis ( J:151434 )

• following carotid injury with ferric chloride, mice develop severe occlusive thrombi with complete degradation of the medial elastic fibers unlike in similarly treated Apoe^tm1Unc homozygotes

cardiovascular system

abnormal vascular wound healing ( J:151434 )

• following carotid injury with ferric chloride, neointimal area is greater than in similarly treated Apoe^tm1Unc homozygotes

• however, the medial area of the healing blood vessel is normal

• following carotid injury with ferric chloride, the intima to media ratio is increased compared to in similarly treated Apoe^tm1Unc homozygotes

• following carotid injury with ferric chloride, neointimal hyperplasia induces more pronounced luminal stenosis than in similarly treated Apoe^tm1Unc homozygotes

• following carotid injury with ferric chloride, mice develop severe occlusive thrombi with complete degradation of the medial elastic fibers unlike in similarly treated Apoe^tm1Unc homozygotes

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
familial combined hyperlipidemia		DOID:13809	OMIM:144250	J:151434