Phenotypes Associated with This Genotype

Genotype
MGI:4354283

• Allelic Composition: Rb1^tm2.1Jyjw/Rb1^tm2.1Jyjw
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

abnormal milk ejection ( J:151417 )

♀ • a third of nursing mothers are unable to eject adequate supplies of milk

♀ • another third are only partially able to nurse

♀ • some pups die by two days of age due to insufficient nutrition

♀ • mammary glands have large, dilated ducts containing milk consisted with a defect in milk ejection

♀ • mice have similar lobuloalveolar formation and milk composition as controls

mammary gland duct hyperplasia ( J:151417 )

♀ • female mice have a significantly elevated frequency of hyperplastic ducts about 2-fold greater than controls

♀ • branching frequency and overall ductal morphogenesis appeared normal

mammary gland hyperplasia ( J:151417 )

♀ • mammary glands have hyperplastic growth throughout development

♀ • hyperplasia was characterized by increased luminal epithelial cell layers, as well as invagination of the epithelium into the lumen of the duct

homeostasis/metabolism

abnormal response/metabolism to endogenous compounds ( J:151417 )

• embryonic fibroblasts fail to decrease proliferative rate in response to TGF-beta1

integument

abnormal milk ejection ( J:151417 )

♀ • a third of nursing mothers are unable to eject adequate supplies of milk

♀ • another third are only partially able to nurse

♀ • some pups die by two days of age due to insufficient nutrition

♀ • mammary glands have large, dilated ducts containing milk consisted with a defect in milk ejection

♀ • mice have similar lobuloalveolar formation and milk composition as controls

mammary gland duct hyperplasia ( J:151417 )

♀ • female mice have a significantly elevated frequency of hyperplastic ducts about 2-fold greater than controls

♀ • branching frequency and overall ductal morphogenesis appeared normal

mammary gland hyperplasia ( J:151417 )

♀ • mammary glands have hyperplastic growth throughout development

♀ • hyperplasia was characterized by increased luminal epithelial cell layers, as well as invagination of the epithelium into the lumen of the duct

behavior/neurological

abnormal milk ejection ( J:151417 )

♀ • a third of nursing mothers are unable to eject adequate supplies of milk

♀ • another third are only partially able to nurse

♀ • some pups die by two days of age due to insufficient nutrition

♀ • mammary glands have large, dilated ducts containing milk consisted with a defect in milk ejection

♀ • mice have similar lobuloalveolar formation and milk composition as controls