Phenotypes Associated with This Genotype

Genotype
MGI:4354206

• Allelic Composition: Tg(Tyr-BRAF*V600E)476Fgh/0
• Genetic Background: involves: C57BL/6J * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:151455 )

• median survival is 595 days

neoplasm

increased malignant tumor incidence ( J:151455 )

• mice rarely develop melanomas

pigmentation

abnormal melanocyte morphology ( J:151455 )

• mice develop benign melanocyte hyperplasia showing large nests of epithelioid cells generally located in the deep dermis and subcutis