Phenotypes Associated with This Genotype

Genotype
MGI:4354198

• Allelic Composition: Tg(APOE-GHRL)1Jagu/0; Tg(APOE-MBOAT4)1Jagu/0
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

adipose tissue

increased total body fat amount ( J:151420 )

• fat mass is significantly higher than controls 4 weeks after being fed a diet high in medium-chain triglycerides

growth/size/body

increased body weight ( J:151420 )

• body weight is significantly higher than controls 4 weeks after being fed a diet high in medium-chain triglycerides

homeostasis/metabolism

abnormal circulating hormone level ( J:151420 )

• mice contain in circulation des-acyl and acyl forms of human ghrelin

• when fed a diet high in medium-chain triglycerides, ghrelin levels are over 100-fold higher than endogenous with acyl-activation forms also significantly elevated

decreased energy expenditure ( J:151420 )

• mice fed a diet high in medium-chain triglycerides have less energy expenditure than diet-matched controls

• gene expression analysis suggests decreased mitochondrial fat oxidation in skeletal muscle