Analysis Tools
nervous system
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• thalamocortical axonal development is disrupted compared to in wild-type mice
• at E14.5, the cell-sparse zone spanning the diencephalic-telencephalic border appears disorganized and only a narrow cell-sparse shaft extended across the ventral telencephalon unlike in wild-type mice
• at E14.5, an abnormally thin bundle of thalamocortical axons cross the ventral telencephalon with much of the bundle of axons descending through the diencephalon appearing to end at the diencephalic-telencephalic border unlike in wild-type mice
• at E14.5, a small number of axons leave the internal capsule along it's length to grow in a ventral direction unlike in wild-type mice
• at E16.5, the internal capsule appears abnormally narrow and reduced in size compared to in wild-type mice
• at E16.5, diI injections label a bifurcated tract in which some axons course ventrally in the direction of the hypothalamus unlike in wild-type mice
• unlike in wild-type mice, many thalamic axons fail to navigate normal from the diencephalic-telencephalic border to the internal capsule and fail to exit in a ventral direction
• at E16.5, some descending corticofugal axons from the visual cortex become misrouted unlike in wild-type mice
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• at E16.5, the internal capsule appears abnormally narrow and reduced in size compared to in wild-type mice
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