Phenotypes Associated with This Genotype

Genotype
MGI:4354113

• Allelic Composition: Rp1^tm1Jnz/Rp1⁺; Rp1l1^tm1Jnz/Rp1l1⁺
• Genetic Background: involves: 129S7/SvEvBrd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

abnormal photoreceptor outer segment morphology ( J:151463 )

• mice at 6 months of age have OS abnormalities similar to Rp1l1^tm1Jnz homozygotes

• 16% of mice have swirling discs in the OS compared to under 3% for controls

abnormal rod electrophysiology ( J:151463 )

• the a-wave amplitudes of 6 month old mice are similar to those in Rp1l1^tm1Jnz homozygotes (i.e. 70% of normal)

• flash sensitivity of rod photoreceptors is reduced about 50% at 3-4 weeks of age

nervous system

abnormal photoreceptor outer segment morphology ( J:151463 )

• mice at 6 months of age have OS abnormalities similar to Rp1l1^tm1Jnz homozygotes

• 16% of mice have swirling discs in the OS compared to under 3% for controls