Phenotypes Associated with This Genotype

Genotype
MGI:4353992

• Allelic Composition: Rbl1^tm1Mru/Rbl1^tm1Mru
• Genetic Background: involves: 129S4/SvJae * BALB/c

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:129672 )

• 70% of mice die by 3 weeks of age

adipose tissue

decreased gonadal fat pad weight ( J:129672 )

• in testicular and ovarian white adipose tissue fat pad

decreased inguinal fat pad weight ( J:129672 )

• in white adipose tissue fat pad

decreased interscapular fat pad weight ( J:129672 )

• in white adipose tissue fat pad

decreased total fat pad weight ( J:129672 )

• interscapular, inguinal, testicular, ovarian, and intraperitoneal white adipose fat pads are reduced in weight compared to in wild-type mice

• however, interscapular brown adipose tissue depots are normal

decreased percent body fat/body weight ( J:129672 )

abnormal white adipose tissue morphology ( J:129672 )

• white adipose tissue resembles brown adipose tissue with small-sized, unilocular adipocytes with many multilocular appearing cells unlike in wild-type mice

• white adipose tissue differentiation of preadipocytes is deficient in vivo

• however, in vitro preadipocyte differentiation is normal

decreased white adipose tissue amount ( J:129672 )

• neonates and adults exhibit decreased white adipose tissue mass compared to in wild-type mice despite normal suckling, food intake, and nutrient absorption

• mice lack white adipose tissue in the interscapular and inguinal depots and have smaller than normal testicular and ovarian depots

decreased white fat cell size ( J:129672 )

growth/size/body

decreased body size ( J:129672 )

• at P5, mice are runted despite normal suckling

liver/biliary system

hepatic steatosis ( J:129672 )

• at P5, the liver is yellow in appearance due to excessive lipid accumulation unlike in wild-type mice

• however, after weaning liver lipid content is normal

homeostasis/metabolism

increased oxygen consumption ( J:129672 )

• 12% higher than in wild-type mice