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Phenotypes Associated with This Genotype
Genotype
MGI:4353906
Allelic
Composition
Jchaintm1Jse/Jchaintm1Jse
Genetic
Background
involves: 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Jchaintm1Jse mutation (0 available); any Jchain mutation (22 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
liver/biliary system
• IgA levels in the bile are 3.5-fold lower than in controls
• the IgA present in the bile is mostly in a monomer state compared to the dimeric state that predominates in wild-type bile

immune system
• production of dimeric IgA is severely curtailed in these mice
• serum IgA levels are about 35-fold higher (J:34042)
• IgA levels found in bronchoalveolar lavage fluid are 8- to 18- fold higher than in controls (J:34042)
• IgA is often in monomeric form in the serum and mucosal fluids (J:34042)
• IgA levels in mucosal secretions and breast milk are not significantly different from controls (J:34042)
• serum IgA levels are over 30-fold higher than in controls (J:75843)
• monomer to dimer is 10:1 ratio compared to 1:1 in wild-type (J:75843)

digestive/alimentary system
• while levels of IgA are normal in intestinal fluids, monomeric forms of IgA are found in these fluids that are not found in wild-type controls (J:34042)
• fecal levels of IgA are 5.5-fold lower than in controls (J:75843)

endocrine/exocrine glands
• monomeric forms of IgA are found in the breast milk while the dimeric form of IgA predominates in wild-type breast milk

integument
• monomeric forms of IgA are found in the breast milk while the dimeric form of IgA predominates in wild-type breast milk

hematopoietic system
• production of dimeric IgA is severely curtailed in these mice
• serum IgA levels are about 35-fold higher (J:34042)
• IgA levels found in bronchoalveolar lavage fluid are 8- to 18- fold higher than in controls (J:34042)
• IgA is often in monomeric form in the serum and mucosal fluids (J:34042)
• IgA levels in mucosal secretions and breast milk are not significantly different from controls (J:34042)
• serum IgA levels are over 30-fold higher than in controls (J:75843)
• monomer to dimer is 10:1 ratio compared to 1:1 in wild-type (J:75843)


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
05/07/2024
MGI 6.23
The Jackson Laboratory