Phenotypes Associated with This Genotype

Genotype
MGI:4353825

• Allelic Composition: Tg(Dct-Birc5)21Gros/0; Tg(Mt1-Hgf)19Lmb/0
• Genetic Background: involves: C57BL/6 * CBA * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased skin tumor incidence ( J:122181 )

• following a single UV exposure, tumor formation is accelerated compared to Tg(MT-HGFSF)19Lmb animals, with a mean onset of formation of 18 weeks

• tumor density is 7.7 lesions/mouse compared to 5.2 in Tg(MT-HGFSF)19Lmb mutants

increased metastatic potential ( J:122181 )

• lymph node metastasis by melanocytic cells is observed in about one third of mice

• significantly higher rates of lung metastasis (53% vs 22%) are detected compared to Tg(MT-HGFSF)19Lmb mice

• prominent involvement of blood vessels and lymphatics in metastasis by melanoma cells is frequently noted

increased melanoma incidence ( J:122181 )

• melanocytic tumors are visible on the skin and histologically, infiltration of large melanized cells is observed

increased incidence of tumors by UV-induction ( J:122181 )

• melanocytes in mice show a predisposition to UV-induced melanocytic tumor formation

cellular

decreased cellular sensitivity to ultraviolet irradiation ( J:122181 )

• following a single UV exposure, melanocytes in neonatal skin show significantly reduced sensitivity to UV-induced apoptosis compared to Tg(MT-HGFSF)19Lmb single-mutant mice

• following UV exposure, metastasized melanomas show reduced apoptotic cell numbers compared to non-metastasized melanomas from Tg(MT-HGFSF)19Lmb mice

integument

increased skin tumor incidence ( J:122181 )

• following a single UV exposure, tumor formation is accelerated compared to Tg(MT-HGFSF)19Lmb animals, with a mean onset of formation of 18 weeks

• tumor density is 7.7 lesions/mouse compared to 5.2 in Tg(MT-HGFSF)19Lmb mutants