Phenotypes Associated with This Genotype

Genotype
MGI:4353818

• Allelic Composition: \Tg(Dct-Birc5)21Gros/0
• Genetic Background: involves: C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

neoplasm ( J:122181 )

N • transgenic animals show no increase in susceptibility to DMBA-induced lesions (nevi) compared to control animals; lesion formation occurs in 90% of mice and lesion onset is about 10 weeks for both mutants and controls

N • untreated mice observed for up to 9 months do not spontaneous develop nevi

N • following a single UV exposure, mice remain tumor-free for duration of observation period

cellular

decreased cellular sensitivity to ultraviolet irradiation ( J:122181 )

• cultured melanocytes show reduced sensitivity to UV-induced apoptosis compared to controls