Phenotypes Associated with This Genotype

Genotype
MGI:4353422

• Allelic Composition: Themis^5AT161/Themis^5AT161
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased CD4-positive, alpha-beta T cell number ( J:151076 )

• there is a lower percentage of CD44^loCD4⁺ T cells in the blood than in controls

• nave CD4 T cell population is only 12% that of controls

decreased CD8-positive, alpha-beta T cell number ( J:151076 )

• the nave CD8 T cell population is 30% of that in controls

decreased regulatory T cell number ( J:151076 )

• regulatory T cell numbers are decreased more in the thymus than the CD4 single positive thymocyte population

decreased single-positive T cell number ( J:151076 )

• the CD4 and CD8 single-positive thymocyte populations are significantly smaller than in controls

• significant loss in the immature CD4+ subset in the thymus

hematopoietic system

decreased CD4-positive, alpha-beta T cell number ( J:151076 )

• there is a lower percentage of CD44^loCD4⁺ T cells in the blood than in controls

• nave CD4 T cell population is only 12% that of controls

decreased CD8-positive, alpha-beta T cell number ( J:151076 )

• the nave CD8 T cell population is 30% of that in controls

decreased regulatory T cell number ( J:151076 )

• regulatory T cell numbers are decreased more in the thymus than the CD4 single positive thymocyte population

decreased single-positive T cell number ( J:151076 )

• the CD4 and CD8 single-positive thymocyte populations are significantly smaller than in controls

• significant loss in the immature CD4+ subset in the thymus