Phenotypes for Ets1 Ets2 Tg(Tek-cre)1Ywa MGI:4353416 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Ets1^tm1Jml/Ets1^tm1Jml Ets2^tm5.1Rgo/Ets2^tm5.1Rgo Tg(Tek-cre)1Ywa/0
Genetic Background	involves: 129S/SvEv * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ets1^tm1Jml mutation (0 available); any Ets1 mutation (25 available)
Ets2^tm5.1Rgo mutation (0 available); any Ets2 mutation (37 available)
Tg(Tek-cre)1Ywa mutation (6 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:151187 )

• die before E14.5

cellular

increased vascular endothelial cell apoptosis ( J:151187 )

• increase in endothelial cell apoptosis at E11.5 and E13.5

cardiovascular system

abnormal vascular branching morphogenesis ( J:151187 )

• defect in branching seen at E10.5 and E11.5

• increase in inter blood vessel spacing

increased vascular endothelial cell apoptosis ( J:151187 )

• increase in endothelial cell apoptosis at E11.5 and E13.5

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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