Phenotypes Associated with This Genotype

Genotype
MGI:4353388

• Allelic Composition: Tg(TcraH-Y,TcrbH-Y)71Vbo/?; Themis^tm1Lov/Themis^tm1Lov
• Genetic Background: involves: 129 * C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal negative T cell selection ( J:151075 )

• the percentage of DP thymocytes is consistently higher in male mice than in male transgenics on a wild-type background, which suggests that negative selection occurs less efficiently

abnormal positive T cell selection ( J:151075 )

• higher double positive thymocyte numbers and fewer single-positive thymoyctes in females indicate a defect in positive selection

increased double-positive T cell number ( J:151075 )

• double-positive thymocytes are increased in female mice

decreased single-positive T cell number ( J:151075 )

• CD8 single-positive thymocyte nubmers are reduced in these female mice

hematopoietic system

abnormal negative T cell selection ( J:151075 )

• the percentage of DP thymocytes is consistently higher in male mice than in male transgenics on a wild-type background, which suggests that negative selection occurs less efficiently

abnormal positive T cell selection ( J:151075 )

• higher double positive thymocyte numbers and fewer single-positive thymoyctes in females indicate a defect in positive selection

increased double-positive T cell number ( J:151075 )

• double-positive thymocytes are increased in female mice

decreased single-positive T cell number ( J:151075 )

• CD8 single-positive thymocyte nubmers are reduced in these female mice