Analysis Tools
mortality/aging
|
• all of the homozygous pups born died within 1 hour of birth
• no excess intrauterine mortality was observed at E18
|
nervous system
|
• the brains of the homozygous mice at the time of birth and at E16.5 were grossly dysmorphic
• at E12.5, dorsal structures in the rostral brain were hypoplastic and lacked morphological differentiation of medial and paramedial dorsal structures resulting in abnormal head appearance externally
• principal telencephalic defects in homozygous mutants involved severe hypoplasia of the dorsal midline structures and adjacent cerebral cortex
|
|
• the size of the basal ganglia was disproportionately large compared with the cortex in mutant brain at E12.5
|
