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Phenotypes Associated with This Genotype
Genotype
MGI:4353301
Allelic
Composition		 Tg(CTSG-PML/RARA)135Ley/0
Tg(CTSG-RARA/PML)2544Ley/0
Genetic
Background		 involves: C3H * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(CTSG-PML/RARA)135Ley mutation (1 available)
Tg(CTSG-RARA/PML)2544Ley mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased acute promyelocytic leukemia incidence ( J:59080 )
• 7 of 36 (19.4%) and 16 of 28 (57%) doubly transgenic mice of independent cohorts developed acute premyelocytic leukemia (APML) b7 of 36 (19.4%) and 16 of 28 (57%) doubly transgenic mice of independent cohorts developed acute premyelocytic leukemia (APML) by 12 and 24 months of age, respectively

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory