Phenotypes Associated with This Genotype

Genotype
MGI:4352743

• Allelic Composition: Gt(ROSA)26Sor^tm1(DTA)Jpmb/Gt(ROSA)26Sor⁺; Tg(Smad7-cre)1Sjc/0
• Genetic Background: involves: 129S/Sv * C3HeB/FeJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Cardiovascular abnormalities in Gt(ROSA)26Sor^tm1(DTA)Jpmb/Gt(ROSA)26Sor⁺ Tg(Smad7-cre)1Sjc/0 embryos

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:150864 )

• cardiovascular developmental abnormalities result in in utero death

embryo

abnormal vitelline vasculature morphology ( J:150864 )

• yolk sacs of mutant embryos have almost no vasculature compared to controls

pharyngeal arch hypoplasia ( J:150864 )

• observed in E10.5 embryos

cardiovascular system

cardiovascular system phenotype ( J:150864 )

N • in mutants, ventricular myocardium and endothelial layer are intact

abnormal blood vessel morphology ( J:150864 )

• vessels are weakened and hemorrhagic in embryos

abnormal dorsal aorta morphology ( J:150864 )

• dorsal aorta is fragmented and contains only a few smooth muscle cells

abnormal vitelline vasculature morphology ( J:150864 )

• yolk sacs of mutant embryos have almost no vasculature compared to controls

absent atrioventricular cushions ( J:150864 )

• atrioventricular (AV) cushion region is largely absent in mutants

atrioventricular cushion hypoplasia ( J:150864 )

• cushion hypoplasia is observed at E10

small heart ( J:150864 )

• E10.5 embryos have smaller hearts relative to controls

hemorrhage ( J:150864 )

• E10.5 embryos are hemorrhagic

craniofacial

pharyngeal arch hypoplasia ( J:150864 )

• observed in E10.5 embryos