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Phenotypes Associated with This Genotype
Genotype
MGI:4352712
Allelic
Composition		 \Gnastm1Lsw/\Gnas+
Genetic
Background		 involves: 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gnastm1Lsw mutation (0 available); any Gnas mutation (53 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
decreased urine osmolality ( J:56867 )
• when the allele is inherited paternally, mice treated with a V2 receptor-selective vasopressin agonist exhibit reduced urine osmolarity compared to in similarly treated wild-type mice

renal/urinary system
decreased urine osmolality ( J:56867 )
• when the allele is inherited paternally, mice treated with a V2 receptor-selective vasopressin agonist exhibit reduced urine osmolarity compared to in similarly treated wild-type mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory