Analysis Tools
cellular
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• genomic stability is disrupted in activated B cells with chromosome breakage occurring in close to half of cells
• B cells undergoing class switch recombination have even greater increased risk of chromosome breakage due to aberrations at the Igh locus
• there is decreased breakage at Igl locus compared to conditional knockouts on a Rag-sufficient background
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hematopoietic system
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• class switch recombination often leads to chromosome breakage at the Igh locus
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immune system
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• class switch recombination often leads to chromosome breakage at the Igh locus
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