Phenotypes for Aicda Tg(Cr2-cre)3Cgn Xrcc4 MGI:4352686 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Aicda^tm1Hon/Aicda^tm1Hon Tg(Cr2-cre)3Cgn/? Xrcc4^tm1Fwa/Xrcc4^tm2Fwa
Genetic Background	involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aicda^tm1Hon mutation (7 available); any Aicda mutation (57 available)
Tg(Cr2-cre)3Cgn mutation (2 available)
Xrcc4^tm1Fwa mutation (0 available); any Xrcc4 mutation (27 available)
Xrcc4^tm2Fwa mutation (0 available); any Xrcc4 mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

spontaneous chromosome breakage ( J:150339 )

• genomic stability is disrupted in activated B cells with chromosome breakage occurring in close to half of cells

• however, there is no increased breakage of the Igh locus compared to wild-type controls

• there is increased breakage at the Igk and Igl loci with 1% of stimulated B cells demonstrating this

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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