Phenotypes Associated with This Genotype

Genotype
MGI:3852641

• Allelic Composition: Apoe^tm1Unc/Apoe^tm1Unc; Tnfrsf11b^tm1Eac/Tnfrsf11b^tm1Eac
• Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal aorta morphology ( J:128053 )

• increased extractable calcium in the aorta at 40 and 60 weeks

abnormal brachiocephalic trunk morphology ( J:128053 )

• 38% show calcification of the medial layer of the brachiocephalic artery

• calcification of the intimal layer of the brachiocephalic artery by 40-60 weeks

atherosclerotic lesions ( J:128053 )

• increased area of lesions in the brachiocephalic artery at 40 and 60 weeks but not at 20 weeks

• increased number of lesions with laminated elastic fibers

• larger areas of collagen and proteoglycan deposition

• 40% addition reduction in lesion cellularity as compared to mice only homozygous for Apoe^tm1Unc