Analysis Tools
mortality/aging
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• following infection with T. gondii, mice exhibit increased mortality compared with wild-type mice
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immune system
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• TNP-KLH-stimulated mice fail to exhibit antigen-specific class switching unlike similarly treated wild-type mice
• however, class switching in mice treated with TNP-Ficoll is normal
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• the ratio of B to T cells is reduced compared to in wild-type mice
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• B220+ B cells are reduced in the spleen and lymph nodes compared to in wild-type mice
• B cell reduction increased with age regardless of IgM or IgD expression
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• CD3+ T cells are increased in the spleen and lymph nodes compared to in wild-type mice
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• the white pulp is infiltrated with macrophage subpopulations that are normally completely excluded in wild-type mice
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• no metallophillic macrophages are detected in the marginal zone unlike in wild-type mice
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• splenic B cell follicles are decreased compared to in wild-type mice with a ring of B220+ cells surrounding the white pulp within the spleen
• however, when cells are adoptively transferred into Rag null mice can generate normal follicular areas
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• in response to T-dependent antigens
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• fewer marginal zone macrophages are detected in the outer ring of the marginal zone compared to in wild-type mice
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• influenza-challenged mice produce fewer flu-specific IgG2a production compared with similarly treated wild-type mice
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• in TNP-KLH-stimulated mice
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• following infection with T. gondii, mice exhibit increased mortality compared with wild-type mice
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hematopoietic system
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• TNP-KLH-stimulated mice fail to exhibit antigen-specific class switching unlike similarly treated wild-type mice
• however, class switching in mice treated with TNP-Ficoll is normal
|
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• the ratio of B to T cells is reduced compared to in wild-type mice
|
|
• B220+ B cells are reduced in the spleen and lymph nodes compared to in wild-type mice
• B cell reduction increased with age regardless of IgM or IgD expression
|
|
• CD3+ T cells are increased in the spleen and lymph nodes compared to in wild-type mice
|
|
• the white pulp is infiltrated with macrophage subpopulations that are normally completely excluded in wild-type mice
|
|
• no metallophillic macrophages are detected in the marginal zone unlike in wild-type mice
|
|
• splenic B cell follicles are decreased compared to in wild-type mice with a ring of B220+ cells surrounding the white pulp within the spleen
• however, when cells are adoptively transferred into Rag null mice can generate normal follicular areas
|
|
• in response to T-dependent antigens
|
|
• fewer marginal zone macrophages are detected in the outer ring of the marginal zone compared to in wild-type mice
|
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• influenza-challenged mice produce fewer flu-specific IgG2a production compared with similarly treated wild-type mice
|
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• in TNP-KLH-stimulated mice
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