Phenotypes Associated with This Genotype

Genotype
MGI:3852394

• Allelic Composition: Dlg4^tm2.1Grnt/Dlg4^tm2.1Grnt
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

enhanced behavioral response to cocaine ( J:89778 )

• enhancement of behavioral responses to acute cocaine exposure

impaired behavioral response to cocaine ( J:89778 )

• chronic exposure to cocaine does not result in the development of sensitization as is seen in wild-type mice

decreased vertical activity ( J:89778 )

• in an open field test

decreased locomotor activity ( J:89778 )

• in an open field test

nervous system

enhanced long-term potentiation ( J:89778 )

• striking enhancement in tetanus induced cortico-accumbal long term potentiation throughout the post tetanic recording session