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Phenotypes Associated with This Genotype
Genotype
MGI:3852186
Allelic
Composition
Ccr6tm1(EGFP)Irw/Ccr6tm1(EGFP)Irw
Genetic
Background
B6.129S6-Ccr6tm1(EGFP)Irw
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccr6tm1(EGFP)Irw mutation (1 available); any Ccr6 mutation (22 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• splenocytes from mice infected with Y. enterocolitica produce much less IFN-gamma than controls
• splenocytes from mice infected with Y. enterocolitica produce much less IL-12 than controls
• splenocytes from mice infected with Y. enterocolitica produce much less IL-4 than controls
• splenocytes from mice infected with Y. enterocolitica produce much less TFN than controls
• mice are resistant to oral Y. enterocolitica infection
• six days after infection wild-type mice appear humpbacked and shaggy with large Peyer's patches and lesions present in the intestines, liver and spleen
• mutant mice do not display these infectious symptoms even with 20-fold higher oral doses
• splenocytes from infected mice make much less IL-4, IL-12, TNF, and IFN-gamma than wild-type controls
• mutant mice do become sick after i.p. infection with Y. enterocolitica


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
07/09/2019
MGI 6.14
The Jackson Laboratory