Analysis Tools
immune system
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• splenocytes from mice infected with Y. enterocolitica produce much less IFN-gamma than controls
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• splenocytes from mice infected with Y. enterocolitica produce much less IL-12 than controls
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• splenocytes from mice infected with Y. enterocolitica produce much less IL-4 than controls
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• splenocytes from mice infected with Y. enterocolitica produce much less TFN than controls
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• mice are resistant to oral Y. enterocolitica infection
• six days after infection wild-type mice appear humpbacked and shaggy with large Peyer's patches and lesions present in the intestines, liver and spleen
• mutant mice do not display these infectious symptoms even with 20-fold higher oral doses
• splenocytes from infected mice make much less IL-4, IL-12, TNF, and IFN-gamma than wild-type controls
• mutant mice do become sick after i.p. infection with Y. enterocolitica
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