Phenotypes Associated with This Genotype

Genotype
MGI:3852119

• Allelic Composition: Nr3c1^tm2Gsc/Nr3c1^tm2Gsc; Tg(Drd1a-cre)AGsc/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:150544 )

N • Anxiety-related behavior, basic motor processes (movement, coordination), and associative learning are not impaired in mutants

abnormal behavioral response to addictive substance ( J:150544 )

• mice show profoundly decreased cocaine self-administration; acquistion of cocaine self-administration is similar to controls but dose-response is decreased indicating a lower reinforcing efficacy of cocaine

nervous system

abnormal nervous system electrophysiology ( J:150544 )

• spontaneous firing rate of dopamine neurons is highly reduced in ventral tegmental area (VTA)

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:150544 )

N • circulating glucocorticoid levels are normal under basal and stress conditions

N • anxiety-related behaviors are not altered compared to controls indicating behavioral changes are specific to cocaine reinforcement