Phenotypes Associated with This Genotype

Genotype
MGI:3852094

• Allelic Composition: Myrf^tm1Barr/Myrf^tm1Barr; Olig2^{tm2(TVA,cre)Rth}/Olig2⁺
• Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:150563 )

• mice die during third postnatal week

behavior/neurological

tremors ( J:150563 )

• severe tremors are observed around P11

ataxia ( J:150563 )

• observed around P11

seizures ( J:150563 )

• develop after P10

nervous system

nervous system phenotype ( J:150563 )

N • gross CNS architecture is normal

N • motor neuron population in spinal cord is intact

N • peripheral nerves are fully myelinated

seizures ( J:150563 )

• develop after P10

abnormal optic nerve morphology ( J:150563 )

• at P13, optic nerve axons show almost no myelination in contrast to wild-type controls where about 50% of axons are myelinated

abnormal spinal cord morphology ( J:150563 )

• severe loss of myelin basic protein (immunostaining) is observed in spinal cord at P13, but spinal root myelination (myelinated by Schwann cells) is normal

abnormal myelination ( J:150563 )

• essentially complete loss of myelination in CNS white matter tracts is observed at P13

vision/eye

abnormal optic nerve morphology ( J:150563 )

• at P13, optic nerve axons show almost no myelination in contrast to wild-type controls where about 50% of axons are myelinated