Phenotypes Associated with This Genotype

Genotype
MGI:3852065

• Allelic Composition: Per1^tm1Drw/Per1^tm1Drw; Per2^tm1Drw/Per2^tm1Drw
• Genetic Background: involves: 129S4/SvJae

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

arrhythmic circadian behavior persistence ( J:69626 , J:95746 )

• mice immediately lose their rhythmicity when transferred into dark-dark conditions (J:69626)

• in free-running conditions, mice become arrhythmic immediately under dark-dark conditions unlike similarly treated wild-type mice (J:95746)

abnormal sleep pattern ( J:95746 )

• during the 12-hour light segment, mice wake more and have less slow wave sleep compared to wild-type mice

• during the last two-third of the lights-on period, mice exhibit more wakefulness than wild-type mice

• at midday, mice exhibit less REM sleep than wild-type mice

• in dark dark conditions, mice exhibit arrhythmic pattern of time spent in wakefulness, short wave sleep, and REM sleep unlike similarly treated wild-type mice

• however, the amount of sleep obtained in dark-dark conditions is normal

• during entrained conditions, mice exhibit longer wake bouts during the dark period compared with the light period unlike in wild-type mice

• during entrained conditions, mice exhibit longer short wave sleep and REM sleep bouts during the light segment compared with wild-type mice

• arrhythmic mice exhibit even distribution of wake, short wave sleep, and REM bouts during subjective light and dark periods unlike wild-type mice

homeostasis/metabolism

abnormal circadian temperature homeostasis ( J:95746 )

• the acrophase of core temperature is phase-advanced compared to in wild-type mice

nervous system

abnormal brain delta wave pattern ( J:95746 )

• recovery after 6 hours of prolonged waking, mice exhibit an increase in delta power lasting 12 hours during the recovery sleep period compared with wild-type mice in which it lasts 3 hours