Phenotypes Associated with This Genotype

Genotype
MGI:3852063

• Allelic Composition: Per1^tm1Drw/Per1^tm1Drw
• Genetic Background: involves: 129S4/SvJae

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

prolonged circadian behavior period ( J:95746 )

• in free-running conditions, the period of temperature rhythm is longer than in wild-type mice

arrhythmic circadian behavior persistence ( J:69626 )

• 9 of 11 mice become arrhythmic after 10 to 14 days when transferred to dark-dark conditions unlike wild-type mice

• for 3 weeks in dark-dark conditions, one mouse exhibited reduced circadian rhythm amplitude compared to in wild-type mice

abnormal sleep pattern ( J:95746 )

• during the 12-hour recovery after 6 hours of prolonged waking, mice exhibit less waking and more short wave sleep compared to similarly treated wild-type mice

abnormal circadian sleep/wake cycle ( J:95746 )

• in free-running dark-dark conditions mice fail to exhibit a change in REM sleep unlike similarly treated wild-type mice

nervous system

abnormal brain delta wave pattern ( J:95746 )

• recovery after 6 hours of prolonged waking, mice exhibit an increase in delta power lasting 9 hours during the recovery sleep period compared with wild-type mice in which it lasts 3 hours