Phenotypes Associated with This Genotype

Genotype
MGI:3852060

• Allelic Composition: Cd22^tm1Eac/Cd22^tm1Eac
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased B cell apoptosis ( J:132991 )

• B cells have less viability in co-cultures with dendritic cells compared to controls

abnormal transitional stage B cell morphology ( J:132991 )

• T1 B cell numbers in the spleen are slightly elevated

• T2 follicular and marginal zone precursors are reduced by 65% and 87%, respectively

decreased mature B cell number ( J:132991 , J:37451 )

• less mature B cells are found in the bone marrow (J:132991)

• mature B cell numbers are reduced more than 3-fold in the bone marrow (J:37451)

abnormal mature B cell morphology ( J:37451 )

• splenic B cells have decreased expression of sIgM and MHC-II

decreased marginal zone B cell number ( J:132991 )

• marginal zone B cell numbers are reduced by about half

decreased memory B cell number ( J:37451 )

• there is a virtual absent of long lived B cells found in the bone marrow and is reduced in the spleen

abnormal B cell activation ( J:37451 )

• B cells are about 10-fold more sensitive to BCR engagement based on mobilization of intracellular calcium

abnormal B cell proliferation ( J:132991 , J:37451 )

• B cells proliferation is not inhibited by the presence of immature wild-type dendritic cells (J:132991)

• B cells have less proliferative response to BCR cross-linking but have enhanced proliferative response to LPS (J:37451)

• less proliferation to BCR cross-linking is associated with increased rates of apoptosis and decreased progress in the cell cycle (J:37451)

decreased IgG1 level ( J:37451 )

• reduced levels of antigen-specific IgG1 occur after immunization with a T cell-independent type II antigen

decreased IgG3 level ( J:37451 )

• reduced levels of antigen-specific IgG3 occur after immunization with a T cell-independent type II antigen

decreased IgM level ( J:37451 )

• reduced levels of antigen-specific IgM occur after immunization with a T cell-independent type II antigen

hematopoietic system

increased B cell apoptosis ( J:132991 )

• B cells have less viability in co-cultures with dendritic cells compared to controls

abnormal transitional stage B cell morphology ( J:132991 )

• T1 B cell numbers in the spleen are slightly elevated

• T2 follicular and marginal zone precursors are reduced by 65% and 87%, respectively

decreased mature B cell number ( J:132991 , J:37451 )

• less mature B cells are found in the bone marrow (J:132991)

• mature B cell numbers are reduced more than 3-fold in the bone marrow (J:37451)

decreased marginal zone B cell number ( J:132991 )

• marginal zone B cell numbers are reduced by about half

decreased memory B cell number ( J:37451 )

• there is a virtual absent of long lived B cells found in the bone marrow and is reduced in the spleen

abnormal mature B cell morphology ( J:37451 )

• splenic B cells have decreased expression of sIgM and MHC-II

abnormal B cell activation ( J:37451 )

• B cells are about 10-fold more sensitive to BCR engagement based on mobilization of intracellular calcium

abnormal B cell proliferation ( J:132991 , J:37451 )

• B cells proliferation is not inhibited by the presence of immature wild-type dendritic cells (J:132991)

• B cells have less proliferative response to BCR cross-linking but have enhanced proliferative response to LPS (J:37451)

• less proliferation to BCR cross-linking is associated with increased rates of apoptosis and decreased progress in the cell cycle (J:37451)

decreased IgG1 level ( J:37451 )

• reduced levels of antigen-specific IgG1 occur after immunization with a T cell-independent type II antigen

decreased IgG3 level ( J:37451 )

• reduced levels of antigen-specific IgG3 occur after immunization with a T cell-independent type II antigen

decreased IgM level ( J:37451 )

• reduced levels of antigen-specific IgM occur after immunization with a T cell-independent type II antigen

cellular

increased B cell apoptosis ( J:132991 )

• B cells have less viability in co-cultures with dendritic cells compared to controls

abnormal B cell proliferation ( J:132991 , J:37451 )

• B cells proliferation is not inhibited by the presence of immature wild-type dendritic cells (J:132991)

• B cells have less proliferative response to BCR cross-linking but have enhanced proliferative response to LPS (J:37451)

• less proliferation to BCR cross-linking is associated with increased rates of apoptosis and decreased progress in the cell cycle (J:37451)