Phenotypes Associated with This Genotype

Genotype
MGI:3851984

• Allelic Composition: Zbtb18^tm1Haok/Zbtb18^tm1Haok
• Genetic Background: involves: 129/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:150768 )

• mice die shortly after birth of unknown causes

nervous system

abnormal cortical ventricular zone morphology ( J:150768 )

• the ventricular zone expands radially in the cortex compared to in wild-type mice

• at E18.5, the ventricular zone is expanded compared to in wild-type mice

abnormal cerebellar foliation ( J:150768 )

• the cerebellum lacks the typical foliation observed in wild-type mice

abnormal hippocampus morphology ( J:150768 )

• the hippocampal fissure is poorly developed compared to in wild-type mice

• laminar structures of the hippocampus are disorganized compared to in wild-type mice

abnormal hippocampus granule cell layer ( J:150768 )

• absent

abnormal hippocampus pyramidal cell layer ( J:150768 )

• absent

small hippocampus ( J:150768 )

abnormal neocortex morphology ( J:150768 )

• the neocortex is hypoplastic, is reduced in thickness, and contains disorganized layers compared to in wild-type mice

abnormal postnatal subventricular zone morphology ( J:150768 )

• expanded at P0 due to increased cell proliferation

decreased neuron number ( J:150768 )

• the number of mature neurons is decreased in neocortex and hippocampus compared to in wild-type mice

• at E16.5, the number of the subplate neurons is decreased and neurons are displaced compared to in wild-type mice

abnormal neuron physiology ( J:150768 )

• neuron proliferation is increased in the subventricular zone compared to in wild-type mice

• reentry into the cell cycle in the cortex is enhanced compared to in wild-type mice

• unlike in wild-type mice, cell-cycle exit is dominantly impaired in the subventricular and intermediate zones but not the ventricular zone at E16.5

• however, cell-cycle exit of progenitor cells in the cortex is normal

increased neuron apoptosis ( J:150768 )

• in the cortex at E18.5

cellular

increased neuron apoptosis ( J:150768 )

• in the cortex at E18.5