Phenotypes Associated with This Genotype

Genotype
MGI:3851898

• Allelic Composition: Prkca^tm1Jmk/Prkca^tm1Jmk
• Genetic Background: involves: 129

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:88510 , J:132098 )

N • normal baseline blood pressure and heart rate (J:88510)

N • heart weight/body weight ratios are not altered in mutants at 16 weeks after myocardial infarction (MI) but ratio is significantly higher in wild-type at this point (J:132098)

abnormal myocardium layer morphology ( J:132098 )

• mutant mice show equivalent infarcted area/area at risk ratio to wild-type after myocardial infarction

abnormal cardiac muscle contractility ( J:132098 )

• after myocardial infarction (MI), ventricular function is maintained in mutants compared to wild-type; fractional shortening is rescued at most time points evaluated after MI

decreased response of heart to induced stress ( J:88510 )

• mice were less susceptible to TAC-induced pressure overload heart failure than wild-type controls

muscle

abnormal myocardium layer morphology ( J:132098 )

• mutant mice show equivalent infarcted area/area at risk ratio to wild-type after myocardial infarction

abnormal cardiac muscle contractility ( J:132098 )

• after myocardial infarction (MI), ventricular function is maintained in mutants compared to wild-type; fractional shortening is rescued at most time points evaluated after MI

homeostasis/metabolism

decreased response of heart to induced stress ( J:88510 )

• mice were less susceptible to TAC-induced pressure overload heart failure than wild-type controls