Phenotypes Associated with This Genotype

Genotype
MGI:3851793

• Allelic Composition: Cm/+; Tg(Snap25)40Micw/Tg(Snap25)40Micw
• Genetic Background: involves: C3H/HeJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:58598 , J:32588 )

N • tail-pinched induced theta wave in halothane anesthetized mice is normal, unlike that of Cm/+ mice without the transgene (J:58598)

N • paired pulse inhibition is normal and amphetamine treatment does not increase paired-pulse inhibition as it does in Cm/+ mice without the transgene (J:58598)

N • the hyperactivity and suppressive effect of amphetamines found in the Cm/+ mice is rescued by homozygous expression of this transgene (J:32588)

head bobbing ( J:32588 )

• despite homozygous expression of this transgene, these mice still display the head bobbing phenotype of Cm/+

vision/eye

abnormal eye development ( J:32588 )

• sunken, closed eyes characteristic of Cm/+ mice are still found despite the homozygous presence of this transgene

coloboma ( J:32588 )