Phenotypes Associated with This Genotype

Genotype
MGI:3851780

• Allelic Composition: Elk4^tm1Rtr/Elk4^tm1Rtr; Tg(TcrLCMV)327Sdz/?
• Genetic Background: involves: 129/Sv * C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal positive T cell selection ( J:88515 )

• CD8 thymocyte positive selection is impaired: the proportion of CD8⁺ single positive thymocytes is reduced by about 75% and gating on TCR^hi cells show almost 90% reduction

decreased CD8-positive, alpha-beta T cell number ( J:88515 )

• the proportion of CD8⁺ single positive thymocytes is reduced by about 75% and gating on TCR^hi cells show almost 90% reduction

immune system

abnormal positive T cell selection ( J:88515 )

• CD8 thymocyte positive selection is impaired: the proportion of CD8⁺ single positive thymocytes is reduced by about 75% and gating on TCR^hi cells show almost 90% reduction

decreased CD8-positive, alpha-beta T cell number ( J:88515 )

• the proportion of CD8⁺ single positive thymocytes is reduced by about 75% and gating on TCR^hi cells show almost 90% reduction