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Phenotypes Associated with This Genotype
Genotype
MGI:3851534
Allelic
Composition		 Icostm1Flv/Icostm1Flv
Tg(Cd4-Maf)6666Glm/0
Genetic
Background		 involves: 129S1/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Icostm1Flv mutation (4 available); any Icos mutation (30 available)
Tg(Cd4-Maf)6666Glm mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal cytokine secretion ( J:112600 )
• T cells activated for 4 days with anti-CD3 and wild-type antigen presenting cells produce more IL-4 than controls but production of IL-17a and interferon gamma is much lower

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/06/2026
MGI 6.24 		The Jackson Laboratory