Phenotypes Associated with This Genotype

Genotype
MGI:3851530

• Allelic Composition: Stat6^tm1Gru/Stat6^tm1Gru
• Genetic Background: involves: 129S2/SvPas

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal cytokine secretion ( J:112600 )

• T cells from mice immunized with keyhole limpet hemocyanin (KLH) in CFA (conjugated Freund's adjuvant) produce less IL-4 and interferon gamma than wild-type in response to KLH restimulation; IL-17a levels are comparable to controls

reproductive system

abnormal mammary gland growth during pregnancy ( J:184505 )

♀ • decrease in alveologenesis at 5dG but not at 15dG

cellular

decreased mammary gland epithelial cell proliferation ( J:184505 )

♀ • decrease in the proliferative potential of luminal progenitor cells in vitro

endocrine/exocrine glands

decreased mammary gland epithelial cell proliferation ( J:184505 )

♀ • decrease in the proliferative potential of luminal progenitor cells in vitro

abnormal mammary gland morphology ( J:184505 )

♀ • increase in the population of cells expressing GATA3, ESR1, and PGR and absence of cells expressing STAT5

abnormal mammary gland growth during pregnancy ( J:184505 )

♀ • decrease in alveologenesis at 5dG but not at 15dG

abnormal mammary gland epithelium morphology ( J:184505 )

♀ • increase in the number of luminal progenitor cells

integument

decreased mammary gland epithelial cell proliferation ( J:184505 )

♀ • decrease in the proliferative potential of luminal progenitor cells in vitro

abnormal mammary gland morphology ( J:184505 )

♀ • increase in the population of cells expressing GATA3, ESR1, and PGR and absence of cells expressing STAT5

abnormal mammary gland growth during pregnancy ( J:184505 )

♀ • decrease in alveologenesis at 5dG but not at 15dG

abnormal mammary gland epithelium morphology ( J:184505 )

♀ • increase in the number of luminal progenitor cells