Mouse Genome Informatics
hm
    Whsc1tm1Ykan/Whsc1tm1Ykan
involves: 129S2/SvPas * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
mortality/aging
• some mice are stillborn
• no mice live past 10 days of age

cardiovascular system
• hypoplasia of the septum secundum was observed more frequently in E18.5 embryos than in controls
• all E18.5 embryos have atrial septum defects
• half of E18.5 embryos have membranous ventricular septum defects

craniofacial
• cleft palate is observed in E18.5 embryos

digestive/alimentary system
• cleft palate is observed in E18.5 embryos

growth/size
• cleft palate is observed in E18.5 embryos
• after birth, mice exhibit growth retardation before dying
• E18.5 embryos are significantly smaller than controls

skeleton
• E18.5 embryos do not have ossification centers

Mouse Models of Human Disease
OMIM IDRef(s)
Wolf-Hirschhorn Syndrome; WHS 194190 J:150360