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Phenotypes Associated with This Genotype
Genotype
MGI:3851446
Allelic
Composition
Tg(Camk2a-tTA)1Mmay/0
Tg(tetO-HTT*94Q,-lacZ)1Rhn/0
Genetic
Background
involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Camk2a-tTA)1Mmay mutation (6 available)
Tg(tetO-HTT*94Q,-lacZ)1Rhn mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• some mice die between 8 to 10 months due to injuries sustain from fighting with other mice (J:61490)
• some mice die between 8 to 10 months due to injuries sustain from fighting with other mice (J:61490)
• fewer than expected mice are recovered due to prenatal lethality (J:61490)
• however, treatment of pregnant dams with doxycycline eliminates prenatal lethality (J:61490)
• fewer than expected mice are recovered due to prenatal lethality (J:61490)
• however, treatment of pregnant dams with doxycycline eliminates prenatal lethality (J:61490)

nervous system
• ventricles are enlarged compared to in wild-type mice (J:61490)
• ventricles are enlarged compared to in wild-type mice (J:61490)
• the striatum is reduced in size compared to in wild-type mice (J:61490)
• the ventricular zone of the striatum is narrower than in wild-type mice (J:61490)
• the striatum is reduced in size compared to in wild-type mice (J:61490)
• the ventricular zone of the striatum is narrower than in wild-type mice (J:61490)
• the area of the caudate putamen is reduced compared to in wild-type mice (J:61490)
• however, treatment with doxycycline after the onset of symptoms restores some of the caudate putamen area (J:61490)
• the area of the caudate putamen is reduced compared to in wild-type mice (J:61490)
• however, treatment with doxycycline after the onset of symptoms restores some of the caudate putamen area (J:61490)
• gliosis spreads throughout the lateral and medial striatum over time (J:61490)
• gliosis spreads throughout the lateral and medial striatum over time (J:61490)
• mice exhibit reactive astrocytosis in the striatum that spreads over time (J:61490)
• however, treatment with doxycycline after the onset of symptoms reduces astrocytosis (J:61490)
• mice exhibit reactive astrocytosis in the striatum that spreads over time (J:61490)
• however, treatment with doxycycline after the onset of symptoms reduces astrocytosis (J:61490)
• mice develop neuronal intranuclear and extranuclear inclusion (J:61490)
• however, treatment with doxycycline after the onset of symptoms alleviates inclusions (J:61490)
• mice develop neuronal intranuclear and extranuclear inclusion (J:61490)
• however, treatment with doxycycline after the onset of symptoms alleviates inclusions (J:61490)

behavior/neurological
• in older mice with tremors (J:61490)
• in older mice with tremors (J:61490)
• beginning at 4 weeks, some mice exhibit limb grasping when suspended (J:61490)
• by 8 weeks, all mice display clasping that can last after mice are released (J:61490)
• however, treatment with doxycycline after the onset of symptoms reduces glasping behavior and duration (J:61490)
• beginning at 4 weeks, some mice exhibit limb grasping when suspended (J:61490)
• by 8 weeks, all mice display clasping that can last after mice are released (J:61490)
• however, treatment with doxycycline after the onset of symptoms reduces glasping behavior and duration (J:61490)
• mild tremors begin at 20 weeks in some mice (J:61490)
• in some mice tremors develop into a jerking motion (J:61490)
• mild tremors begin at 20 weeks in some mice (J:61490)
• in some mice tremors develop into a jerking motion (J:61490)
• mice exhibit progressive motor dysfunction with choreic and dystonic movements, and parkinsonism (J:61490)
• mice exhibit progressive motor dysfunction with choreic and dystonic movements, and parkinsonism (J:61490)
• at 36 weeks (J:61490)
• at 36 weeks (J:61490)

muscle
• mice exhibit progressive motor dysfunction with choreic and dystonic movements, and parkinsonism (J:61490)
• mice exhibit progressive motor dysfunction with choreic and dystonic movements, and parkinsonism (J:61490)

Mouse Models of Human Disease
OMIM ID Ref(s)
Huntington Disease; HD 143100 J:61490


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory