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Phenotypes Associated with This Genotype
Genotype
MGI:3851409
Allelic
Composition		 Gata4tm1Sho/Gata4tm1.1Wtp
Tg(Myh6-cre)2182Mds/0
Genetic
Background		 involves: 129S6/SvEvTac * 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata4tm1.1Wtp mutation (0 available); any Gata4 mutation (37 available)
Gata4tm1Sho mutation (0 available); any Gata4 mutation (37 available)
Tg(Myh6-cre)2182Mds mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Reduced coronary microvasculature, decreased capillary density and increased fibrosis in Gata4tm1.1Wtp/Gata4tm1Sho Tg(Myh6-cre)2182Mds/0 hearts

cardiovascular system
dilated heart ventricle ( J:150452 )
• ventricular dilation is observed
abnormal cardiovascular system physiology ( J:150452 )
• severely diminished systolic function at 8-14 weeks

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/20/2026
MGI 6.24 		The Jackson Laboratory