Phenotypes Associated with This Genotype

Genotype
MGI:3851407

• Allelic Composition: Zfpm2^tm1Sho/Zfpm2^tm2Sho; Tg(Tnnt2-rtTA,tetO-cre)1Wtp/0
• Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Increased fibrotic tissues in doxycycline-treated Zfpm2^tm1Sho/Zfpm2^tm2Sho Tg(Tnnt2-rtTA,tetO-cre)1Wtp/0 hearts

cardiovascular system

abnormal cardiovascular development ( J:150452 )

• decreased coronary vasculature is observed in doxycycline-treated mice relative to controls

decreased cardiac muscle contractility ( J:150452 )

• significantly diminished fractional shortening is observed in mice receiving doxycycline-treated water from 4 to 8 weeks of age

• fractional shortening progressively decreases in animals treated with doxycycline

increased cardiomyocyte apoptosis ( J:150452 )

• level of apoptosis is elevated compared to controls

muscle

decreased cardiac muscle contractility ( J:150452 )

• significantly diminished fractional shortening is observed in mice receiving doxycycline-treated water from 4 to 8 weeks of age

• fractional shortening progressively decreases in animals treated with doxycycline

increased cardiomyocyte apoptosis ( J:150452 )

• level of apoptosis is elevated compared to controls

cellular

increased cardiomyocyte apoptosis ( J:150452 )

• level of apoptosis is elevated compared to controls