Analysis Tools
mortality/aging
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• mice survive normally to weaning but die at 8-12 weeks
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cardiovascular system
| N |
• at E14.5 no structural heart defects or coronary vascular plexus abnormalities are observed
• myocardium thickens normally and contains normal number of intramyocardial vessels
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• decreased coronary vasculature is observed in adults
• density of PECAM positive vessels particularly capillaries are reduced in density; coronary arteriole density is also decreased
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• significantly increased and replaces apoptotic tissues
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• adult hearts are dilated
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• ventricular dilation is observed
|
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• decreased myocardial perfusion is observed in adults, resulting in tissue hypoxia
|
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• fractional shortening is severely depressed in adults
|
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• contraction is depressed in adults
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• significantly increased in adult heart compared to controls
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muscle
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• fractional shortening is severely depressed in adults
|
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• contraction is depressed in adults
|
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• significantly increased in adult heart compared to controls
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cellular
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• significantly increased in adult heart compared to controls
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