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Phenotypes Associated with This Genotype
Genotype
MGI:3851240
Allelic
Composition		 Casp1tm1Sesh/Casp1tm1Sesh
Casp4del/Casp4del
Slc11a1r/Slc11a1s
Genetic
Background		 involves: 129/Sv * 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Casp1tm1Sesh mutation (5 available); any Casp1 mutation (41 available)
Casp4del mutation (5 available); any Casp4 mutation (34 available)
Slc11a1r mutation (2 available); any Slc11a1 mutation (38 available)
Slc11a1s mutation (0 available); any Slc11a1 mutation (38 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased susceptibility to bacterial infection ( J:112400 )
• mice succumb to 2x1010 CFU Salmonella infection with a median survival of 20 days compared to no death by infection for the control mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory