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Phenotypes Associated with This Genotype
Genotype
MGI:3851239
Allelic
Composition
Casp1tm1Sesh/Casp1tm1Sesh
Casp4del/Casp4del
Slc11a1s/Slc11a1s
Genetic
Background
B6.129S2-Casp1tm1Sesh Casp4del
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Casp1tm1Sesh mutation (5 available); any Casp1 mutation (41 available)
Casp4del mutation (5 available); any Casp4 mutation (34 available)
Slc11a1s mutation (0 available); any Slc11a1 mutation (38 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• macrophages are resistant to cytotoxicity induced by in vitro Salmonella infection
• mice succumb more rapidly than controls to 108 CFU of Salmonella with a median survival time of 6 days compared to 8 days for controls
• there is an average 30-fold-higher bacterial loads in infected Peyer's patches, mesenteric lymph nodes, and spleens than in the infected organs of wild-type animals

hematopoietic system
• macrophages are resistant to cytotoxicity induced by in vitro Salmonella infection


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/25/2025
MGI 6.24
The Jackson Laboratory