Phenotypes Associated with This Genotype

Genotype
MGI:3851215

• Allelic Composition: Msh3^tm1Rak/Msh3^tm1Rak
• Genetic Background: involves: 129/Sv * C57BL/6J * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

digestive/alimentary system

increased intestinal adenocarcinoma incidence ( J:60604 )

• in 4 of 39 mice unlike in wild-type mice

mortality/aging

mortality/aging ( J:60604 )

N • mice exhibit normal life span

neoplasm

increased intestinal adenocarcinoma incidence ( J:60604 )

• in 4 of 39 mice unlike in wild-type mice

cellular

abnormal mismatch repair ( J:60604 )

• mismatch repair is partially defective

homeostasis/metabolism

abnormal mismatch repair ( J:60604 )

• mismatch repair is partially defective