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Phenotypes Associated with This Genotype
Genotype
MGI:3851211
Allelic
Composition
Tg(Scn1a*)RH9Aesc/0
Genetic
Background
involves: FVB/NJ
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phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• decreased threshold for kainic acid induced seizures compared to control transgenic lines
• the ratio of sodium current densities in bipolar versus pyramidal neurons is reduced and the sodium current density in bipolar cells is reduced compared to controls
• sodium channels appear to recover more slowly from inactivation and current through the channels decreases during a series of depolarizations in bipolar neurons
• in pyramidal neurons a negative shift is seen in the voltage dependence of inactivation

behavior/neurological
• decreased threshold for kainic acid induced seizures compared to control transgenic lines


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory