Phenotypes Associated with This Genotype

Genotype
MGI:3851205

• Allelic Composition: \Notch2^tm1.1Hhi/\Notch2^tm1.1Hhi; \Tg(Cd8a-cre)1Itan/0
• Genetic Background: involves: C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal CD8-positive, alpha-beta T cell physiology ( J:141009 )

• cells produce less granzyme B than control cells after stimulation with allogeneic control dendritic cells (DCs) or DL1-DCs

abnormal cytotoxic T cell physiology ( J:141009 )

• mice, injected with spleen cells that were pulsed with OT-I (ova) peptide and 4 days later given labeled spleen cells or labeled spleen cells that were pulsed with OT-I (ova) peptide show little CTL-mediated killing of either population; in contrast, control mice display preferential cytolysis of OT-I pulsed spleen cells

increased susceptibility to parasitic infection ( J:141009 )

• mice display much earlier death after Trypanosoma cruzi infection compared to controls

hematopoietic system

abnormal CD8-positive, alpha-beta T cell physiology ( J:141009 )

• cells produce less granzyme B than control cells after stimulation with allogeneic control dendritic cells (DCs) or DL1-DCs

abnormal cytotoxic T cell physiology ( J:141009 )

• mice, injected with spleen cells that were pulsed with OT-I (ova) peptide and 4 days later given labeled spleen cells or labeled spleen cells that were pulsed with OT-I (ova) peptide show little CTL-mediated killing of either population; in contrast, control mice display preferential cytolysis of OT-I pulsed spleen cells