Phenotypes Associated with This Genotype

Genotype
MGI:3851173

• Allelic Composition: Gata6^tm1Msp/Gata6^tm1Msp
• Genetic Background: involves: 129X1/SvJ * C57BL/6 * CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:51304 )

• mice die between E6.5 and E7.5

embryo

increased embryonic tissue cell apoptosis ( J:51304 )

• in embryos at E6.5 and E7.5

increased embryonic epiblast cell apoptosis ( J:51304 )

• at E7.0, the epiblast frequently contains pyknotic nuclei unlike in wild-type mice

abnormal endoderm development ( J:51304 )

• expression of endodermal markers is disrupted

embryonic growth retardation ( J:51304 )

decreased embryo size ( J:51304 )

• 10% to 20% at E6.5

small embryonic epiblast ( J:51304 )

• at E7.0, the epiblast is reduced

cellular

increased embryonic tissue cell apoptosis ( J:51304 )

• in embryos at E6.5 and E7.5

increased embryonic epiblast cell apoptosis ( J:51304 )

• at E7.0, the epiblast frequently contains pyknotic nuclei unlike in wild-type mice

growth/size/body

embryonic growth retardation ( J:51304 )

decreased embryo size ( J:51304 )

• 10% to 20% at E6.5