Phenotypes Associated with This Genotype

Genotype
MGI:3851140

• Allelic Composition: Cul4a^tm1.2Pz/Cul4a^tm1.2Pz
• Genetic Background: B6.Cg-Cul4a^tm1.2Pz

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal cell cycle checkpoint function ( J:150427 )

• in response to UV irradiation, embryonic fibroblasts (MEFs) spend 6 hours longer in the G1 phase before progressing into the S phase

abnormal DNA repair ( J:150427 )

• embryonic fibroblasts (MEFs) have about a 20% enhanced efficiency of the global genomic repair pathway

• MEFs spend 6 hours longer at the G1/S checkpoint after UV irradiation

homeostasis/metabolism

abnormal DNA repair ( J:150427 )

• embryonic fibroblasts (MEFs) have about a 20% enhanced efficiency of the global genomic repair pathway

• MEFs spend 6 hours longer at the G1/S checkpoint after UV irradiation